Adrenal Cortex Antibody or Anti-Adrenal Antibody (ADR) test is generally used to diagnose autoimmune adrenal insufficiency.
Adrenal Cortex Antibodies destroy adrenal tissue, interfering with hormone production, by damaging various adrenal proteins, particularly the 21-hydroxy enzymes. The antibodies are predominantly IgG class and, in general, have rather low titres (not higher than 100). The prevalence rises to 90% in patients with hypoadrenalism and primary ovarian failure.
Measurement is useful in determining adrenal involvement in autoimmune polyendocrine syndromes (APS).